About Enhancer
| Enhancer ID: | E_02051 |
| Species: | Mus musculus |
| Position : | chr1:63240000-63243000   |
| Year: | 2019 |
| Title: | Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naive pluripotency |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 31422875 |
| MONDO: | |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Hematopoietic Stem Cells |
| CVCL ID: | |
| Cell Type: | hematopoietic stem cell |
| Cell Ontology ID: | CL:0001029 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | 4C-seq, ATAC-seq, ChIP-seq, RNA-seq, WGBS |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Bisulfite Pyrosequencing |
About Target Gene
| Target gene : | Zdbf2 |
About TF
| TF name : | Pou5F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou5F1 | HIF-2-alpha transcription factor network | pid | 34 |
| Pou5F1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Pou5F1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Pou5F1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Pou5F1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Pou5F1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02050 | chr1:63240000-63243000 | Embryo | mouse embryonic stem cell | -- |
Expression of Target Genes for the Enhancer