About Enhancer
| Enhancer ID: | E_02063 |
| Species: | Mus musculus |
| Position : | chr18:60917264-60917600   |
| Year: | 2019 |
| Title: | Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 31324781 |
| MONDO: | |
| Tissue: | Skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | Langerhans cells |
| CVCL ID: | |
| Cell Type: | Langerhans cell |
| Cell Ontology ID: | CL:0000453 |
| Experiment Type: | Functional perturbation assay, Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, Transgenic Reporter Assay, RT-RT-qPCR, Western blot, Flow Cytometry, Immunohistochemistry |
About Target Gene
| Target gene : | Csf1R |
About TF
| TF name : | Spi1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Spi1 | C-MYB transcription factor network | pid | 87 |
| Spi1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| Spi1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| Spi1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| Spi1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| Spi1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Spi1 | IL4-mediated signaling events | pid | 66 |
| Spi1 | IL4 | netpath | 75 |
| Spi1 | Interleukin signaling pathway | panther | 86 |
| Spi1 | RANKL | netpath | 84 |
| Spi1 | Regulation of retinoblastoma protein | pid | 67 |
| Spi1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Spi1 | Pathways in cancer | kegg | 321 |
| Spi1 | Acute myeloid leukemia | kegg | 53 |
| Spi1 | Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 | wikipathways | 26 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer