About Enhancer
| Enhancer ID: | E_02095 |
| Species: | Mus musculus |
| Position : | chr11:112200000-112204700   |
| Year: | 2025 |
| Title: | GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 39827212 |
| MONDO: | |
| Tissue: | Embryonic gonad |
| Tissue Ontology ID: | UBERON:0005321 |
| Cell Source: | Embryonic gonad cells (E11.5) |
| CVCL ID: | |
| Cell Type: | embryonic gonad cell |
| Cell Ontology ID: | CL:0000000 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, CUT&RUN |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, qRT-PCR |
About Target Gene
| Target gene : | Sox9 |
About TF
| TF name : | Gata4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata4 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata4 | Notch-mediated HES/HEY network | pid | 48 |
| Gata4 | Physiological factors | reactome | 12 |
| Gata4 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| Gata4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Gata4 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Gata4 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Gata4 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer