About Enhancer
| Enhancer ID: | E_02105 |
| Species: | Homo sapiens |
| Position : | chr8:23422136-23432636   |
| Year: | 2016 |
| Title: | Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. |
| Genome Build: | hg18 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 26766440 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Adult bone marrow CD34+-derived proerythroblasts (A5 ProE) |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Super-enhancer profiling; TF binding assay; Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | H3K27ac ChIP-seq; H3K4me1 ChIP-seq; GATA1 ChIP-seq; TAL1 ChIP-seq; RNA-seq |
| Low Throughput Method: | Orthologous mouse enhancer CRISPR/Cas9 deletion; ChIP-qPCR; RT-qPCR; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | SLC25A37 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg18)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02106 | chr8:23422136-23432636 | bone marrow | erythroblast | NA |
Expression of Target Genes for the Enhancer