About Enhancer
| Enhancer ID: | E_02114 |
| Species: | Homo sapiens |
| Position : | chrX:49268807-49270673   |
| Year: | 2026 |
| Title: | FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry. |
| Genome Build: | hg38 |
| Enhancer Type: | Silencer |
| Condition: | Normal |
| PMID: | 41237776 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary conventional CD4+ T cells |
| Cell Type: | CD4-positive, alpha-beta T cell |
| Cell Ontology ID: | CL:0000624 |
| Experiment Type: | Silencer activity assay; Functional perturbation assay; TF binding assay |
| High Throughput Method: | Pooled CRISPRi locus-tiling screen; pooled CRISPRn TF screen; ATAC-seq; H3K27ac ChIP-seq; EGR2 ChIP-seq; RNA-seq |
| Low Throughput Method: | Paired-Cas9 RNP tiled deletion; CRISPRoff targeted epigenetic silencing; EGR2 knockout; FOXP3 flow cytometry; targeted bisulfite sequencing; targeted amplicon sequencing |
About Target Gene
| Target gene : | FOXP3 |
About TF
| TF name : | EGR2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EGR2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| EGR2 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| EGR2 | IL4-mediated signaling events | pid | 66 |
| EGR2 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| EGR2 | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| EGR2 | Hs_Fatty_Acid_Beta_Oxidation_WP143_79783 | wikipathways | 14 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02126 | chrX:49268807-49270673 | NA | NA | NA |
Expression of Target Genes for the Enhancer