About Enhancer
| Enhancer ID: | E_02116 |
| Species: | Mus musculus |
| Position : | chr8:109142000-109142200   |
| Year: | 2018 |
| Title: | GRHL2-dependent enhancer switching maintains a pluripotent stem cell transcriptional subnetwork after exit from naive pluripotency |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 30017589 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | ESCs |
| CVCL ID: | |
| Cell Type: | embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | Cdh1 |
About TF
| TF name : | Klf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Klf4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Klf4 | Synthesis, secretion, and deacylation of Ghrelin | reactome | 17 |
| Klf4 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Klf4 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Klf4 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| Klf4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| Klf4 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer