About Enhancer
| Enhancer ID: | E_02117 |
| Species: | Homo sapiens |
| Position : | chrX:49273000-49274000   |
| Year: | 2026 |
| Title: | FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 41237776 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary conventional CD4+ T cells |
| Cell Type: | CD4-positive, alpha-beta T cell |
| Cell Ontology ID: | CL:0000624 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; TF binding assay |
| High Throughput Method: | Pooled CRISPRi locus-tiling screen; pooled CRISPRn TF screen; ATAC-seq; H3K27ac ChIP-seq; GATA3 ChIP-seq |
| Low Throughput Method: | Paired-Cas9 RNP tiled deletion; CRISPRoff targeted epigenetic silencing; GATA3 knockout; FOXP3 flow cytometry; targeted amplicon sequencing; targeted bisulfite sequencing |
About Target Gene
| Target gene : | FOXP3 |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer