About Enhancer
| Enhancer ID: | E_02124 |
| Species: | Mus musculus |
| Position : | chr5:150830909-150831422   |
| Year: | 2025 |
| Title: | An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 37772400 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | hiPSC-CMs |
| CVCL ID: | |
| Cell Type: | cardiomyocyte |
| Cell Ontology ID: | CL:0000746 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | Transgenic reporter assay, CRISPR knockout, CRISPRi, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | Nkx2-5 |
About TF
| TF name : | Gata6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata6 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata6 | Notch-mediated HES/HEY network | pid | 48 |
| Gata6 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Gata6 | Surfactant metabolism | reactome | 30 |
| Gata6 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02123 | chr5:150830909-150831422 | Heart | cardiomyocyte | -- |
Expression of Target Genes for the Enhancer