About Enhancer
| Enhancer ID: | E_02136 |
| Species: | Homo sapiens |
| Position : | chr22:36328713-36329931   |
| Year: | 2025 |
| Title: | Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | idiopathic pulmonary fibrosis |
| PMID: | 40997217 |
| MONDO: | MONDO:0800504 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | primary lung fibroblasts from idiopathic pulmonary fibrosis donors |
| Cell Type: | fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Disease-context functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | single-cell RNA-seq; RNA-seq |
| Low Throughput Method: | dCas9-KRAB CRISPRi; RT-qPCR; alpha-smooth muscle actin immunostaining; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | MYH9 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer