About Enhancer
| Enhancer ID: | E_02138 |
| Species: | Mus musculus |
| Position : | chr1:190181703-190182534   |
| Year: | 2023 |
| Title: | A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 36697821 |
| MONDO: | |
| Tissue: | Lymphatic vasculature |
| Tissue Ontology ID: | UBERON:0001473 |
| Cell Source: | Lymphatic endothelial cells (LECs) |
| CVCL ID: | |
| Cell Type: | lymphatic endothelial cell |
| Cell Ontology ID: | CL:0002546 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | Transgenic Reporter Assay, CRISPR Knockout, ChIP-RT-qPCR, qRT-PCR, Immunostaining |
About Target Gene
| Target gene : | Prox1 |
About TF
| TF name : | Gata2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata2 | AP-1 transcription factor network | pid | 71 |
| Gata2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata2 | HIF-1-alpha transcription factor network | pid | 67 |
| Gata2 | IL3 | netpath | 84 |
| Gata2 | Regulation of Androgen receptor activity | pid | 54 |
| Gata2 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata2 | Signaling events mediated by HDAC Class II | pid | 58 |
| Gata2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer