About Enhancer
| Enhancer ID: | E_02154 |
| Species: | Homo sapiens |
| Position : | chr16:11075000-11075280   |
| Year: | 2025 |
| Title: | Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Burkitt lymphoma |
| PMID: | 39796169 |
| MONDO: | MONDO:0007243 |
| Tissue: | lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | Namalwa (B-lymphocyte) |
| CVCL ID: | CVCL_0128 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; Luciferase Reporter Assay |
| Low Throughput Method: | CRISPR Knockout, siRNA Knockdown; RT-RT-qPCR; CRISPRa (dCas9-VPR, dCas9-TET1); CRISPRi (dCas9-DNMT3A, dCas9-MeCP2); Western blot; Luciferase reporter assay; Reporter assay; ChIP-qPCR; qPCR; siRNA knockdown |
About Target Gene
| Target gene : | CLEC16A |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer