About Enhancer
| Enhancer ID: | E_02165 |
| Species: | Homo sapiens |
| Position : | chr20:46000017-46000761   |
| Year: | 2025 |
| Title: | Characterization of a cis-regulatory element upstream of matrix metalloproteinase-9. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 41354677 |
| Tissue: | placenta |
| Tissue Ontology ID: | UBERON:0001987 |
| Cell Source: | HTR-8/SVneo |
| CVCL ID: | CVCL_3286 |
| Cell Type: | trophoblast |
| Cell Ontology ID: | CL:0000358 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; TF-binding/motif analysis |
| High Throughput Method: | H3K27ac ChIP-seq; comparative epigenomic profiling |
| Low Throughput Method: | Luciferase reporter assay; CRISPR-Cas9 enhancer deletion; RT-qPCR; TF-motif perturbation |
About Target Gene
| Target gene : | MMP9 |
About TF
| TF name : | TEAD4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TEAD4 | PPARA activates gene expression | reactome | 113 |
| TEAD4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| TEAD4 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer