About Enhancer
| Enhancer ID: | E_02170 |
| Species: | Mus musculus |
| Position : | chr11:101234567-101235689   |
| Year: | 2025 |
| Title: | C/EBP?? activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40378239 |
| MONDO: | |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Myeloid cells |
| CVCL ID: | |
| Cell Type: | myeloid cell |
| Cell Ontology ID: | CL:0000837 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | CRISPR knockout, ChIP-RT-qPCR |
About Target Gene
| Target gene : | Irf8 |
About TF
| TF name : | Cebpa |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Cebpa | AndrogenReceptor | netpath | 167 |
| Cebpa | C-MYB transcription factor network | pid | 87 |
| Cebpa | E2F transcription factor network | pid | 77 |
| Cebpa | EGFR1 | netpath | 475 |
| Cebpa | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Cebpa | IL4 | netpath | 75 |
| Cebpa | Regulation of Androgen receptor activity | pid | 54 |
| Cebpa | Regulation of retinoblastoma protein | pid | 67 |
| Cebpa | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Cebpa | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Cebpa | Pathways in cancer | kegg | 321 |
| Cebpa | Acute myeloid leukemia | kegg | 53 |
| Cebpa | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| Cebpa | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| Cebpa | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| Cebpa | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer