About Enhancer
| Enhancer ID: | E_02171 |
| Species: | Homo sapiens |
| Position : | chr21:40149729-40317726   |
| Year: | 2023 |
| Title: | A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | inflammatory bowel disease |
| PMID: | 36609474 |
| MONDO: | MONDO:0005265 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Ulcerative-colitis-derived colon organoids |
| Cell Type: | colon epithelial cell |
| Cell Ontology ID: | CL:0011108 |
| Experiment Type: | Disease-associated super-enhancer activity; TF binding; chromatin interaction |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq; promoter capture Hi-C; MECOM ChIP-seq; 5' CAGE |
| Low Throughput Method: | dCas9-KRAB CRISPRi; 3CqPCR; CUT&Tag-qPCR; RT-qPCR; Western blot |
About Target Gene
| Target gene : | ETS2 |
About TF
| TF name : | MECOM |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MECOM | PKMTs methylate histone lysines | reactome | 64 |
| MECOM | MAPK signaling pathway | kegg | 264 |
| MECOM | Pathways in cancer | kegg | 321 |
| MECOM | Chronic myeloid leukemia | kegg | 69 |
| MECOM | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer