About Enhancer
| Enhancer ID: | E_02172 |
| Species: | Homo sapiens |
| Position : | chr14:98602411-98675204   |
| Year: | 2023 |
| Title: | Structural variation cooperates with permissive chromatin to control enhancer hijacking-mediated oncogenic transcription. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 36947815 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | DND-41 |
| CVCL ID: | CVCL_2022 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer-hijacking assay; Chromatin interaction assay; Chromatin-state assay; CRISPRi functional perturbation assay; Disease-variant functional analysis |
| High Throughput Method: | Genome sequencing; ATAC-seq; H3K27ac ChIP-seq; RNA-seq; Hi-C; 4C-seq |
| Low Throughput Method: | CRISPRi of BCL11B enhancers; qRT-PCR; allelic expression/methylation analysis |
About Target Gene
| Target gene : | TLX3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02204 | chr14:98602411-98675204 | bone marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02205 | chr14:98602411-98675204 | bone marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02298 | chr14:98602411-98675204 | blood | T cell / T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02343 | chr14:98602411-98675204 | blood | T cell / T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02349 | chr14:98602411-98675204 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00388 | chr14:98664280-98665247 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer