About Enhancer
| Enhancer ID: | E_02177 |
| Species: | Mus musculus |
| Position : | chr5:86800000-87200000   |
| Year: | 2025 |
| Title: | Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40163145 |
| MONDO: | |
| Tissue: | Mammary Gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | Mammary alveolar epithelial cells |
| CVCL ID: | |
| Cell Type: | mammary alveolar epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | RT-RT-qPCR, Western blot, CRISPR knockout |
About Target Gene
| Target gene : | Csn2 |
About TF
| TF name : | Stat5A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Stat5A | Angiopoietin receptor Tie2-mediated signaling | pid | 50 |
| Stat5A | CD40/CD40L signaling | pid | 36 |
| Stat5A | CXCR4-mediated signaling events | pid | 87 |
| Stat5A | Downstream signal transduction | reactome | 29 |
| Stat5A | EGF receptor signaling pathway | panther | 109 |
| Stat5A | EGFR1 | netpath | 475 |
| Stat5A | EPO signaling pathway | pid | 33 |
| Stat5A | EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) | inoh | 12 |
| Stat5A | ErbB4 signaling events | pid | 35 |
| Stat5A | Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 14 |
| Stat5A | Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Stat5A | Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Stat5A | Glucocorticoid receptor regulatory network | pid | 85 |
| Stat5A | GMCSF-mediated signaling events | pid | 38 |
| Stat5A | Growth hormone receptor signaling | reactome | 24 |
| Stat5A | Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) | inoh | 9 |
| Stat5A | IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) | inoh | 7 |
| Stat5A | IL-3 signaling pathway(JAK1 JAK2 STAT5) ( IL-3 signaling(JAK1 JAK2 STAT5) ) | inoh | 7 |
| Stat5A | IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) | inoh | 11 |
| Stat5A | IL-7 | netpath | 28 |
| Stat5A | IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) | inoh | 13 |
| Stat5A | IL12-mediated signaling events | pid | 62 |
| Stat5A | IL2-mediated signaling events | pid | 54 |
| Stat5A | IL2 | netpath | 81 |
| Stat5A | IL2 signaling events mediated by STAT5 | pid | 30 |
| Stat5A | IL23-mediated signaling events | pid | 37 |
| Stat5A | IL27-mediated signaling events | pid | 26 |
| Stat5A | IL3-mediated signaling events | pid | 27 |
| Stat5A | IL3 | netpath | 84 |
| Stat5A | IL4-mediated signaling events | pid | 66 |
| Stat5A | IL4 | netpath | 75 |
| Stat5A | IL5-mediated signaling events | pid | 14 |
| Stat5A | IL5 | netpath | 59 |
| Stat5A | IL6 | netpath | 85 |
| Stat5A | IL9 | netpath | 24 |
| Stat5A | Interleukin-2 signaling | reactome | 14 |
| Stat5A | Interleukin-3, 5 and GM-CSF signaling | reactome | 24 |
| Stat5A | Interleukin-7 signaling | reactome | 11 |
| Stat5A | Interleukin signaling pathway | panther | 86 |
| Stat5A | JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 97 |
| Stat5A | JAK/STAT signaling pathway | panther | 15 |
| Stat5A | KitReceptor | netpath | 104 |
| Stat5A | Leptin | netpath | 98 |
| Stat5A | Nuclear signaling by ERBB4 | reactome | 25 |
| Stat5A | PDGF signaling pathway (Mammal) ( PDGF signaling pathway ) | inoh | 29 |
| Stat5A | PDGF signaling pathway | panther | 113 |
| Stat5A | PDGFR-beta signaling pathway | pid | 125 |
| Stat5A | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 178 |
| Stat5A | Prolactin | netpath | 105 |
| Stat5A | Prolactin receptor signaling | reactome | 15 |
| Stat5A | RAC1 signaling pathway | pid | 54 |
| Stat5A | Signaling by cytosolic FGFR1 fusion mutants | reactome | 18 |
| Stat5A | Signaling by Leptin | reactome | 11 |
| Stat5A | Signaling by SCF-KIT | reactome | 37 |
| Stat5A | Signaling events mediated by PTP1B | pid | 53 |
| Stat5A | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| Stat5A | Signaling events mediated by TCPTP | pid | 40 |
| Stat5A | TCR | netpath | 261 |
| Stat5A | TNFalpha | netpath | 274 |
| Stat5A | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| Stat5A | TSLP | netpath | 24 |
| Stat5A | Validated nuclear estrogen receptor alpha network | pid | 65 |
| Stat5A | ErbB signaling pathway | kegg | 83 |
| Stat5A | Jak-STAT signaling pathway | kegg | 149 |
| Stat5A | Pathways in cancer | kegg | 321 |
| Stat5A | Chronic myeloid leukemia | kegg | 69 |
| Stat5A | Acute myeloid leukemia | kegg | 53 |
| Stat5A | Hs_Interferon_type_I_signaling_pathways_WP585_85198 | wikipathways | 35 |
| Stat5A | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
| Stat5A | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
| Stat5A | Hs_ErbB_Signaling_Pathway_WP673_91869 | wikipathways | 37 |
| Stat5A | Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113 | wikipathways | 31 |
| Stat5A | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| Stat5A | Hs_Bladder_Cancer_WP2828_89143 | wikipathways | 17 |
| Stat5A | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
| Stat5A | Hs_IL-5_Signaling_Pathway_WP127_78498 | wikipathways | 35 |
| Stat5A | Hs_IL-2_Signaling_Pathway_WP49_91243 | wikipathways | 33 |
| Stat5A | Hs_Prolactin_Signaling_Pathway_WP2037_90015 | wikipathways | 52 |
| Stat5A | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| Stat5A | Hs_IL-4_Signaling_Pathway_WP395_89828 | wikipathways | 41 |
| Stat5A | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
| Stat5A | Hs_IL-3_Signaling_Pathway_WP286_78583 | wikipathways | 35 |
| Stat5A | Hs_IL-7_Signaling_Pathway_WP205_89854 | wikipathways | 16 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer