About Enhancer
| Enhancer ID: | E_02188 |
| Species: | Mus musculus |
| Position : | chr9:112500000-112502800   |
| Year: | 2023 |
| Title: | Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 37832549 |
| MONDO: | |
| Tissue: | Cartilage |
| Tissue Ontology ID: | UBERON:0002418 |
| Cell Source: | Mouse Mesenchymal Progenitor |
| CVCL ID: | |
| Cell Type: | mesenchymal progenitor cell |
| Cell Ontology ID: | CL:0000134 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq, ATAC-seq |
| Low Throughput Method: | CRISPRa, RT-RT-qPCR |
About Target Gene
| Target gene : | Hmgb2 |
About TF
| TF name : | Sox5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox5 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Sox5 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer