About Enhancer
| Enhancer ID: | E_02195 |
| Species: | Homo sapiens |
| Position : | chr11:5279732-5280272   |
| Year: | 2018 |
| Title: | Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level 污-Globin Gene Expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 30012865 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary human erythroblasts |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Enhancer activity; TF binding; endogenous functional perturbation; chromatin-opening assay |
| High Throughput Method: | ENCODE ChIP-seq/RNA-seq/ATAC-seq integration |
| Low Throughput Method: | Synthetic zinc-finger targeting; CRISPR-Cas9 deletion; EMSA; ChIP-qPCR; RT-qPCR; globin-expression analysis |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | EGR1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EGR1 | AP-1 transcription factor network | pid | 71 |
| EGR1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| EGR1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| EGR1 | ErbB1 downstream signaling | pid | 105 |
| EGR1 | Glucocorticoid receptor regulatory network | pid | 85 |
| EGR1 | Interferon alpha/beta signaling | reactome | 67 |
| EGR1 | Regulation of Androgen receptor activity | pid | 54 |
| EGR1 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 |
| EGR1 | Signaling events mediated by PRL | pid | 23 |
| EGR1 | TCR | netpath | 261 |
| EGR1 | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| EGR1 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| EGR1 | Prion diseases | kegg | 34 |
| EGR1 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
| EGR1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| EGR1 | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02364 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02196 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02197 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02198 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02199 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02211 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02212 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02213 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02214 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02215 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02249 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02251 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02252 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02253 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02254 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02255 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
Expression of Target Genes for the Enhancer