About Enhancer
| Enhancer ID: | E_02195 |
| Species: | Mus musculus |
| Position : | chr10:21241829-21242175   |
| Year: | 2025 |
| Title: | In vivo deletion of a GWAS identified Myb distal enhancer acts on Myb expression, globin switching, and clinical erythroid parameters in ??-thalassemia |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 40089598 |
| MONDO: | |
| Tissue: | Fetal liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Erythroid progenitor |
| CVCL ID: | |
| Cell Type: | erythroid progenitor cell |
| Cell Ontology ID: | CL:0000038 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, Capture-C, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, qRT-PCR, Flow cytometry |
About Target Gene
| Target gene : | Myb |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer