About Enhancer
| Enhancer ID: | E_02197 |
| Species: | Homo sapiens |
| Position : | chr11:5279732-5280272   |
| Year: | 2018 |
| Title: | Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level 污-Globin Gene Expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 30012865 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary human erythroblasts |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Enhancer activity; TF binding; endogenous functional perturbation; chromatin-opening assay |
| High Throughput Method: | ENCODE ChIP-seq/RNA-seq/ATAC-seq integration |
| Low Throughput Method: | Synthetic zinc-finger targeting; CRISPR-Cas9 deletion; EMSA; ChIP-qPCR; RT-qPCR; globin-expression analysis |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | NFE2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
19 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02364 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02195 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02196 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02198 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02199 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02211 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02212 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02213 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02214 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02215 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02249 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02251 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02252 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02253 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02254 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02255 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
Expression of Target Genes for the Enhancer