About Enhancer
| Enhancer ID: | E_02200 |
| Species: | Homo sapiens |
| Position : | chr1:214150511-214151337   |
| Year: | 2015 |
| Title: | GATA2 is required for lymphatic vessel valve development and maintenance. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lymphedema |
| PMID: | 26214525 |
| MONDO: | MONDO:0019297 |
| Tissue: | dermis |
| Tissue Ontology ID: | UBERON:0002067 |
| Cell Source: | Primary adult human dermal lymphatic endothelial cells (hLECs) |
| Cell Type: | endothelial cell |
| Cell Ontology ID: | CL:0000115 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | GATA2 ChIP-seq; ENCODE regulatory annotation integration |
| Low Throughput Method: | Luciferase Reporter Assay; GATA-site mutagenesis; ChIP-qPCR; WEMSA; GATA2 siRNA knockdown; RT-qPCR |
About Target Gene
| Target gene : | PROX1 |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02271 | chr1:214150511-214151337 | dermis | endothelial cell | lymphedema |
| E_02272 | chr1:214150511-214151337 | dermis | endothelial cell | lymphedema |
| E_02284 | chr1:214150511-214151337 | lymphatic vessel | NA | Lymphedema |
| E_02285 | chr1:214150511-214151337 | lymphatic vessel | NA | Lymphedema |
| E_02286 | chr1:214150511-214151337 | lymphatic vessel | NA | Lymphedema |
| E_02266 | chr1:214150857-214151185 | lymphatic vessel | endothelial cell | acute myeloid leukemia |
| E_02273 | chr1:214150857-214151185 | lymphatic vessel | endothelial cell | acute myeloid leukemia |
| E_02274 | chr1:214150857-214151185 | lymphatic vessel | endothelial cell | acute myeloid leukemia |
| E_02275 | chr1:214150857-214151185 | lymphatic vessel | endothelial cell | acute myeloid leukemia |
| E_02276 | chr1:214150857-214151185 | lymphatic vessel | endothelial cell | acute myeloid leukemia |
| E_02277 | chr1:214150857-214151185 | lymphatic vessel | endothelial cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer