About Enhancer
| Enhancer ID: | E_02201 |
| Species: | Homo sapiens |
| Position : | chr5:44385696-44386743   |
| Year: | 2012 |
| Title: | ISL1 directly regulates FGF10 transcription during human cardiac outflow formation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 22303449 |
| Tissue: | outflow tract |
| Tissue Ontology ID: | UBERON:0004145 |
| Cell Source: | human embryonic cardiac outflow tract tissue |
| Cell Type: | second heart field/cardiac progenitor cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; transgenic functional validation |
| High Throughput Method: | Comparative genomics/conservation analysis |
| Low Throughput Method: | ChIP; EMSA; luciferase reporter assay; site-directed mutagenesis; transgenic mouse lacZ reporter assay |
About Target Gene
| Target gene : | FGF10 |
About TF
| TF name : | ISL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ISL1 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| ISL1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| ISL1 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer