About Enhancer
| Enhancer ID: | E_02204 |
| Species: | Homo sapiens |
| Position : | chr14:98602411-98675204   |
| Year: | 2023 |
| Title: | Structural variation cooperates with permissive chromatin to control enhancer hijacking-mediated oncogenic transcription. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 36947815 |
| MONDO: | MONDO:0004963 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | UT242 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ATAC-seq; Hi-C, 4C-seq; RNA-seq |
| Low Throughput Method: | CRISPRi; RT-RT-qPCR; FISH |
About Target Gene
| Target gene : | TLX3 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02172 | chr14:98602411-98675204 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_02205 | chr14:98602411-98675204 | bone marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02298 | chr14:98602411-98675204 | blood | T cell / T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02343 | chr14:98602411-98675204 | blood | T cell / T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02349 | chr14:98602411-98675204 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00388 | chr14:98664280-98665247 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer