About Enhancer
| Enhancer ID: | E_02205 |
| Species: | Mus musculus |
| Position : | chr6:128542796-128543720   |
| Year: | 2018 |
| Title: | A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 29527594 |
| MONDO: | |
| Tissue: | Kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Conventional dendritic cells |
| CVCL ID: | |
| Cell Type: | conventional dendritic cell |
| Cell Ontology ID: | CL:0000451 |
| Experiment Type: | Functional genomics assay, Epigenomic profiling assay, Genome editing assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq, Microarray |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion, RT-RT-qPCR, FGF23 ELISA, Serum biochemical analysis, In vivo LPS stimulation assay, In vivo CKD model assay |
About Target Gene
| Target gene : | Fgf23 |
About TF
| TF name : | Nfkb1; Hif1A; Stat3; Stat5A; Stat6; Arnt; Clock; Arntl; Npas2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer