About Enhancer
| Enhancer ID: | E_02218 |
| Species: | Homo sapiens |
| Position : | chr5:44385696-44386743   |
| Year: | 2012 |
| Title: | ISL1 directly regulates FGF10 transcription during human cardiac outflow formation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 22303449 |
| Tissue: | outflow tract |
| Tissue Ontology ID: | UBERON:0004145 |
| Cell Source: | human embryonic cardiac outflow tract tissue |
| Cell Type: | second heart field/cardiac progenitor cell |
| Experiment Type: | Enhancer activity assay; cooperative TF regulation assay; transgenic functional validation |
| High Throughput Method: | Comparative genomics/conservation analysis |
| Low Throughput Method: | Luciferase reporter assay; transcription-factor co-transfection; transgenic mouse lacZ reporter assay; EMSA |
About Target Gene
| Target gene : | FGF10 |
About TF
| TF name : | GATA4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA4 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA4 | Notch-mediated HES/HEY network | pid | 48 |
| GATA4 | Physiological factors | reactome | 12 |
| GATA4 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| GATA4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| GATA4 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| GATA4 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| GATA4 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer