About Enhancer
| Enhancer ID: | E_02288 |
| Species: | Homo sapiens |
| Position : | chr20:48682144-48683144   |
| Year: | 2023 |
| Title: | Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 37749132 |
| MONDO: | MONDO:0024331 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | SW480 |
| CVCL ID: | CVCL_0546 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay; Disease-variant functional analysis |
| High Throughput Method: | ATAC-seq, ChIP-seq; GWAS |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout |
About Target Gene
| Target gene : | PREX1 |
About TF
| TF name : | ZEB1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ZEB1 | Integrin-linked kinase signaling | pid | 46 |
| ZEB1 | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer