About Enhancer
| Enhancer ID: | E_02292 |
| Species: | Homo sapiens |
| Position : | chr8:128750000-129000000   |
| Year: | 2021 |
| Title: | Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 34911936 |
| MONDO: | MONDO:0008315 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq, HiChIP, 4C-seq, ATAC-seq |
| Low Throughput Method: | CRISPR knockout, RT-RT-qPCR, 3C-ddPCR, Western blot; In vivo phenotyping |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
41 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_05350 | chr8:128748315-128750245 | dermis | dermal lymphatic endothelial cell | NA |
| E_04573 | chr8:128749415-128750415 | colon | NA | colorectal cancer |
| E_02225 | chr8:128750000-128750100 | colon | malignant cell | colorectal cancer |
| E_02187 | chr8:128754000-128755000 | colon | malignant cell | colorectal carcinoma |
| E_02630 | chr8:128754419-128756419 | colon | malignant cell | colorectal cancer |
| E_01099 | chr8:128804720-128805310 | bone marrow | B cell | mantle cell lymphoma |
| E_01100 | chr8:128804720-128805310 | bone marrow | B cell | mantle cell lymphoma |
| E_01101 | chr8:128804720-128805310 | bone marrow | B cell | mantle cell lymphoma |
| E_01102 | chr8:128807460-128808040 | bone marrow | B cell | mantle cell lymphoma |
| E_01103 | chr8:128807460-128808040 | bone marrow | B cell | mantle cell lymphoma |
| E_01104 | chr8:128807460-128808040 | bone marrow | B cell | mantle cell lymphoma |
| E_04885 | chr8:128816178-128817335 | colon | NA | colorectal cancer |
| E_00375 | chr8:128821500-128822500 | breast | breast carcinoma epithelial cell | breast carcinoma |
| E_00459 | chr8:128821500-128822500 | breast | malignant cell | breast carcinoma |
| E_00063 | chr8:128821774-128822358 | breast | malignant cell | breast cancer |
| E_00376 | chr8:128866000-128867000 | breast | breast carcinoma epithelial cell | breast carcinoma |
| E_00460 | chr8:128866000-128867000 | breast | malignant cell | breast carcinoma |
| E_00009 | chr8:128889122-128889450 | kidney | renal cell carcinoma cell | renal cell carcinoma |
| E_00014 | chr8:128889122-128889450 | kidney | clear cell renal cell carcinoma cell of renal tubular origin | Clear cell renal cell carcinoma |
| E_00015 | chr8:128889122-128889450 | kidney | clear cell renal cell carcinoma cell of renal tubular origin | Clear cell renal cell carcinoma |
| E_00016 | chr8:128889122-128889450 | kidney | clear cell renal cell carcinoma cell / malignant renal epithelial cell | clear cell renal cell carcinoma |
| E_00047 | chr8:128889122-128889450 | kidney | clear cell renal cell carcinoma cell / malignant renal epithelial cell | clear cell renal cell carcinoma |
| E_00050 | chr8:128889122-128889450 | kidney | clear cell renal cell carcinoma cell of renal tubular origin | Clear cell renal cell carcinoma |
| E_00051 | chr8:128889122-128889450 | kidney | clear cell renal cell carcinoma cell of renal tubular origin | Clear cell renal cell carcinoma |
| E_00273 | chr8:128889122-128889450 | kidney | renal cell carcinoma cell | renal cell carcinoma |
| E_00374 | chr8:128889122-128889450 | kidney | renal cell carcinoma cell | renal cell carcinoma |
| E_00401 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00402 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00403 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00404 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00405 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00406 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00407 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00408 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_00409 | chr8:128889122-128889450 | kidney | renal epithelial cell | clear cell renal carcinoma |
| E_04568 | chr8:128910869-128911521 | blood | malignant cell | NA |
| E_00377 | chr8:128912000-128913000 | breast | breast carcinoma epithelial cell | breast carcinoma |
| E_00461 | chr8:128912000-128913000 | breast | malignant cell | breast carcinoma |
| E_00378 | chr8:128919000-128920000 | breast | breast carcinoma epithelial cell | breast carcinoma |
| E_00462 | chr8:128919000-128920000 | breast | malignant cell | breast carcinoma |
| E_04569 | chr8:128972341-128973219 | blood | malignant cell | NA |
Expression of Target Genes for the Enhancer