About Enhancer
| Enhancer ID: | E_02303 |
| Species: | Homo sapiens |
| Position : | chr8:129440000-129740000   |
| Year: | 2023 |
| Title: | SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | rhabdoid tumor |
| PMID: | 38040699 |
| MONDO: | MONDO:0002728 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | MRT patient-derived organoids (P60) |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Chromatin interaction assay, Enhancer activity assay, TF binding assay, Functional perturbation assay; Chromatin-state profiling |
| High Throughput Method: | 3C-seq, ATAC-seq, ChIP-seq, RNA-seq; single-cell RNA-seq; RNA-seq; ATAC-seq |
| Low Throughput Method: | 3C-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
52 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03876 | chr8:126650000-129950000 | colon | malignant cell | NA |
| E_00764 | chr8:129581780-129583797 | blood | malignant cell | NA |
| E_00804 | chr8:129581780-129583797 | blood | malignant cell | NA |
| E_00057 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00058 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00059 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00060 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00061 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00062 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00161 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00162 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00163 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00164 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00165 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00166 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00167 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00168 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00169 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00170 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00171 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00172 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00173 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00174 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00175 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00176 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00177 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00178 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00179 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00180 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00181 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00182 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00183 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00184 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00247 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00248 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00249 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00250 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00251 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00252 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00398 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00399 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00427 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00428 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00429 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00430 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00431 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00432 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_02373 | chr8:129631847-129635071 | kidney | NA | IDH-mutant low-grade glioma |
| E_00765 | chr8:129688360-129690572 | blood | malignant cell | NA |
| E_00805 | chr8:129688360-129690572 | blood | malignant cell | NA |
| E_00766 | chr8:129691425-129693640 | blood | malignant cell | NA |
| E_00806 | chr8:129691425-129693640 | blood | malignant cell | NA |
Expression of Target Genes for the Enhancer