About Enhancer
| Enhancer ID: | E_02343 |
| Species: | Homo sapiens |
| Position : | chr14:98602411-98675204   |
| Year: | 2023 |
| Title: | Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T?cell leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 37060567 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | 14) T-ALL cells |
| Cell Type: | T cell / T-lymphoblast |
| Experiment Type: | Chromatin interaction assay; Architectural-factor occupancy assay; Functional perturbation assay |
| High Throughput Method: | CTCF ChIP-seq; Hi-C; 4C-seq; mutation analysis |
| Low Throughput Method: | qRT-PCR; ChIP-qPCR; CTCF-loss genotype-expression association |
About Target Gene
| Target gene : | TLX3 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02172 | chr14:98602411-98675204 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_02204 | chr14:98602411-98675204 | bone marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02205 | chr14:98602411-98675204 | bone marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02298 | chr14:98602411-98675204 | blood | T cell / T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02349 | chr14:98602411-98675204 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00388 | chr14:98664280-98665247 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer