About Enhancer
| Enhancer ID: | E_02348 |
| Species: | Mus musculus |
| Position : | chr17:27040383-27042465   |
| Year: | 2013 |
| Title: | Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 23307821 |
| MONDO: | |
| Tissue: | Heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Cardiac progenitor cells |
| CVCL ID: | |
| Cell Type: | cardiac progenitor cell |
| Cell Ontology ID: | CL:0002248 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay, Transgenic reporter assay, ChIP-RT-qPCR |
About Target Gene
| Target gene : | Nkx2-5 |
About TF
| TF name : | Yy1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Yy1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Yy1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| Yy1 | E2F transcription factor network | pid | 77 |
| Yy1 | mTOR signaling pathway | pid | 66 |
| Yy1 | Notch-mediated HES/HEY network | pid | 48 |
| Yy1 | Notch | netpath | 76 |
| Yy1 | Notch signaling pathway | pid | 58 |
| Yy1 | p53 pathway | pid | 59 |
| Yy1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer