About Enhancer
| Enhancer ID: | E_02362 |
| Species: | Mus musculus |
| Position : | chr10:118409500-118410500   |
| Year: | 2020 |
| Title: | NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 32318068 |
| MONDO: | |
| Tissue: | Lymph Node |
| Tissue Ontology ID: | UBERON:0002429 |
| Cell Source: | In vitro Differentiated Th1 |
| CVCL ID: | |
| Cell Type: | CD4-positive Th1 cell |
| Cell Ontology ID: | CL:0000897 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | RT-RT-qPCR |
About Target Gene
| Target gene : | Ifng |
About TF
| TF name : | Ncor1 |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ncor1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Ncor1 | AndrogenReceptor | netpath | 167 |
| Ncor1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Ncor1 | C-MYB transcription factor network | pid | 87 |
| Ncor1 | Circadian Clock | reactome | 49 |
| Ncor1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| Ncor1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| Ncor1 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | reactome | 23 |
| Ncor1 | ErbB4 signaling events | pid | 35 |
| Ncor1 | HDACs deacetylate histones | reactome | 94 |
| Ncor1 | Notch-mediated HES/HEY network | pid | 48 |
| Ncor1 | Notch | netpath | 76 |
| Ncor1 | Notch signaling pathway | pid | 58 |
| Ncor1 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| Ncor1 | NR1D1 (REV-ERBA) represses gene expression | reactome | 8 |
| Ncor1 | Nuclear signaling by ERBB4 | reactome | 25 |
| Ncor1 | PPARA activates gene expression | reactome | 113 |
| Ncor1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | reactome | 20 |
| Ncor1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Ncor1 | RORA activates gene expression | reactome | 27 |
| Ncor1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Ncor1 | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Ncor1 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Ncor1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| Ncor1 | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02361 | chr10:118409500-118410500 | Spleen | naive CD4-positive T cell | -- |
Expression of Target Genes for the Enhancer