About Enhancer
| Enhancer ID: | E_02364 |
| Species: | Homo sapiens |
| Position : | chr11:5222500-5323700   |
| Year: | 2020 |
| Title: | Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31980609 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | erythroid cell |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPRi; CRISPRa; qRT-PCR; Knock-in mouse |
About Target Gene
| Target gene : | HBG2 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
80 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_04539 | chr11:5224750-5226210 | urinary bladder | malignant cell | NA |
| E_04366 | chr11:5225400-5225774 | bone marrow | malignant cell | NA |
| E_03627 | chr11:5241525-5251525 | bone marrow | erythroblast | NA |
| E_03342 | chr11:5246600-5247600 | kidney | embryonic kidney cell | NA |
| E_05110 | chr11:5248027-5248047 | blood / hematopoietic system | NA | NA |
| E_05111 | chr11:5248027-5248047 | blood / hematopoietic system | NA | NA |
| E_05351 | chr11:5248824-5249485 | NA | NA | NA |
| E_05352 | chr11:5248824-5249485 | NA | NA | NA |
| E_05106 | chr11:5250264-5250295 | blood / hematopoietic system | NA | NA |
| E_05107 | chr11:5250264-5250295 | blood / hematopoietic system | NA | NA |
| E_05108 | chr11:5250535-5250560 | blood / hematopoietic system | NA | NA |
| E_05109 | chr11:5250535-5250560 | blood / hematopoietic system | NA | NA |
| E_05114 | chr11:5250704-5250719 | blood / hematopoietic system | NA | NA |
| E_05115 | chr11:5250704-5250719 | blood / hematopoietic system | NA | NA |
| E_05112 | chr11:5250751-5250777 | blood / hematopoietic system | NA | NA |
| E_05113 | chr11:5250751-5250777 | blood / hematopoietic system | NA | NA |
| E_04971 | chr11:5255062-5258441 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_04518 | chr11:5258353-5258721 | pleural effusion | malignant cell | NA |
| E_04561 | chr11:5264845-5266345 | blood / hematopoietic system | NA | NA |
| E_03158 | chr11:5266021-5266708 | blood / hematopoietic system | NA | NA |
| E_03159 | chr11:5266021-5266708 | blood / hematopoietic system | NA | NA |
| E_03162 | chr11:5266021-5266708 | blood | erythroid cell | NA |
| E_03163 | chr11:5266021-5266708 | blood | erythroid cell | NA |
| E_05358 | chr11:5268575-5268621 | blood / hematopoietic system | erythroid progenitor cell | NA |
| E_04566 | chr11:5270500-5271500 | blood | malignant cell | NA |
| E_04387 | chr11:5271421-5273421 | blood / hematopoietic system | NA | NA |
| E_04511 | chr11:5278952-5279402 | bone marrow | malignant cell | NA |
| E_02195 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02196 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02197 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02198 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02199 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02211 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02212 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02213 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02214 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02215 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02249 | chr11:5279732-5280272 | blood | erythroblast | NA |
| E_02251 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02252 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02253 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02254 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_02255 | chr11:5279732-5280272 | blood / hematopoietic system | NA | Erythrocytic Leukemia |
| E_04687 | chr11:5280741-5280786 | blood | malignant cell | NA |
| E_04273 | chr11:5286080-5288080 | blood / hematopoietic system | NA | NA |
| E_04330 | chr11:5286080-5288080 | blood | erythroid cell | NA |
| E_04247 | chr11:5288664-5288684 | blood / hematopoietic system | erythroid progenitor cell | NA |
| E_04248 | chr11:5288664-5288684 | blood / hematopoietic system | malignant cell | NA |
| E_04250 | chr11:5288664-5288684 | blood | erythroid cell | NA |
| E_04252 | chr11:5288664-5288684 | blood | erythroblast | NA |
| E_04462 | chr11:5293686-5294250 | blood / hematopoietic system | NA | NA |
| E_03631 | chr11:5301485-5302895 | blood | malignant cell | NA |
| E_03230 | chr11:5301600-5302400 | blood / hematopoietic system | NA | NA |
| E_03231 | chr11:5301600-5302400 | blood / hematopoietic system | NA | NA |
| E_03232 | chr11:5301600-5302400 | blood / hematopoietic system | NA | NA |
| E_03070 | chr11:5301801-5302175 | pleural effusion | erythroid lineage cell | NA |
| E_03071 | chr11:5301801-5302175 | pleural effusion | erythroid lineage cell | NA |
| E_03200 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03201 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03202 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03203 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03204 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03205 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03206 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03207 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03210 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_03211 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_03212 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_03213 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_04277 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_04382 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_04567 | chr11:5301862-5302715 | blood | myeloid cell | NA |
| E_04237 | chr11:5301983-5302001 | pleural effusion | erythroid lineage cell | NA |
| E_04238 | chr11:5301983-5302001 | pleural effusion | erythroid lineage cell | NA |
| E_04245 | chr11:5301983-5302001 | uterine cervix | epithelial cell | NA |
| E_04246 | chr11:5301983-5302001 | uterine cervix | epithelial cell | NA |
| E_03632 | chr11:5305481-5306682 | blood | malignant cell | NA |
Expression of Target Genes for the Enhancer