About Enhancer
| Enhancer ID: | E_02373 |
| Species: | Homo sapiens |
| Position : | chr8:129631847-129635071   |
| Year: | 2022 |
| Title: | A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | IDH-mutant low-grade glioma |
| PMID: | 36201590 |
| MONDO: | MONDO:0021637 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | HEK293T |
| CVCL ID: | CVCL_0063 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| Low Throughput Method: | MYC Luciferase Reporter Assay; POU5F1 Overexpression |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | POU5F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU5F1 | HIF-2-alpha transcription factor network | pid | 34 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| POU5F1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| POU5F1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| POU5F1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer