About Enhancer
| Enhancer ID: | E_02382 |
| Species: | Homo sapiens |
| Position : | chr5:159927785-159928129   |
| Year: | 2024 |
| Title: | Three-Dimensional Chromosomal Landscape Revealing miR-146a Dysfunctional Enhancer in Lupus and Establishing a CRISPR-Mediated Approach to Inhibit the Interferon Pathway. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | systemic lupus erythematosus |
| PMID: | 37728419 |
| MONDO: | MONDO:0007915 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary peripheral blood mononuclear cells from patients with SLE |
| Cell Type: | peripheral blood mononuclear cells |
| Experiment Type: | Functional perturbation assay; Endogenous enhancer perturbation; Chromatin interaction assay |
| High Throughput Method: | Hi-C, ATAC-seq; Hi-C |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, RT-RT-qPCR; CRISPRa |
About Target Gene
| Target gene : | MIR146A |
About TF
| TF name : | CEBPA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPA | AndrogenReceptor | netpath | 167 |
| CEBPA | C-MYB transcription factor network | pid | 87 |
| CEBPA | E2F transcription factor network | pid | 77 |
| CEBPA | EGFR1 | netpath | 475 |
| CEBPA | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPA | IL4 | netpath | 75 |
| CEBPA | Regulation of Androgen receptor activity | pid | 54 |
| CEBPA | Regulation of retinoblastoma protein | pid | 67 |
| CEBPA | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPA | Validated targets of C-MYC transcriptional repression | pid | 63 |
| CEBPA | Pathways in cancer | kegg | 321 |
| CEBPA | Acute myeloid leukemia | kegg | 53 |
| CEBPA | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| CEBPA | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| CEBPA | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| CEBPA | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer