About Enhancer
| Enhancer ID: | E_02383 |
| Species: | Homo sapiens |
| Position : | chr3:185824281-185824602   |
| Year: | 2024 |
| Title: | KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | tongue squamous cell carcinoma |
| PMID: | 38443991 |
| MONDO: | MONDO:0000500 |
| Tissue: | tongue |
| Tissue Ontology ID: | UBERON:0001723 |
| Cell Source: | CAL-27 |
| CVCL ID: | CVCL_1107 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay; Enhancer activity assay; Endogenous enhancer perturbation; TF binding assay; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot; CRISPR-Cas9 endogenous deletion/editing; Luciferase reporter assay; ChIP-qPCR; ChIP; In vivo phenotyping; Xenograft/xenotransplant; Reporter assay |
About Target Gene
| Target gene : | IGF2BP2 |
About TF
| TF name : | KLF7 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF7 | Hs_Cytokines_and_Inflammatory_Response_WP530_79331 | wikipathways | 21 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer