About Enhancer
| Enhancer ID: | E_02385 |
| Species: | Homo sapiens |
| Position : | chr11:102245603-102246344   |
| Year: | 2023 |
| Title: | BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | nasopharyngeal carcinoma |
| PMID: | 36788209 |
| MONDO: | MONDO:0015459 |
| Tissue: | nasopharynx |
| Tissue Ontology ID: | UBERON:0001728 |
| Cell Source: | HNE-1 |
| CVCL ID: | CVCL_0308 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity; chromatin-regulator binding; functional perturbation; enhancer/reporter validation; In vivo functional validation |
| High Throughput Method: | BRD7 ChIP-seq; H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | Luciferase reporter assay; BRD7 ChIP-qPCR; BRD7 knockdown/overexpression; RT-qPCR; Western blot; xenograft/metastasis assay; In vivo phenotyping; Xenograft/xenotransplant |
About Target Gene
| Target gene : | BIRC2 |
About TF
| TF name : | BRD7 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| BRD7 | Regulation of TP53 Activity through Acetylation | reactome | 23 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02384 | chr11:102245603-102246344 | nasopharynx | malignant cell | nasopharyngeal carcinoma |
Expression of Target Genes for the Enhancer