About Enhancer
| Enhancer ID: | E_02390 |
| Species: | Homo sapiens |
| Position : | chr9:139390200-139390700   |
| Year: | 2026 |
| Title: | Functional Genomics Link REST to Endothelial Plasticity and Atherosclerosis. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | coronary artery disease |
| PMID: | 41293823 |
| Tissue: | aorta |
| Tissue Ontology ID: | UBERON:0000947 |
| Cell Source: | JHU006i-1 |
| CVCL ID: | CVCL_UA48 |
| Cell Type: | aortic endothelial cell |
| Cell Ontology ID: | CL:0002544 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | ChIP-seq, CUT&Tag, RNA-seq; RNA-seq; eQTL analysis; GWAS |
| Low Throughput Method: | Luciferase reporter assay, CRISPRi, RT-RT-qPCR; CRISPRi; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | NOTCH1 |
About TF
| TF name : | REST |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| REST | HDACs deacetylate histones | reactome | 94 |
| REST | Huntington's disease | kegg | 182 |
| REST | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer