About Enhancer
| Enhancer ID: | E_02391 |
| Species: | Homo sapiens |
| Position : | chr4:56908277-56909126   |
| Year: | 2026 |
| Title: | Functional Genomics Link REST to Endothelial Plasticity and Atherosclerosis. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | coronary artery disease |
| PMID: | 41293823 |
| Tissue: | aorta |
| Tissue Ontology ID: | UBERON:0000947 |
| Cell Source: | Primary human aortic endothelial cells (HAEC |
| Cell Type: | aortic endothelial cell |
| Cell Ontology ID: | CL:0002544 |
| Experiment Type: | Enhancer activity assay; Allele-specific regulatory assay; Genetic association assay; eQTL colocalization assay; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | CAD GWAS; endothelial eQTL meta-analysis; CAFEH multi-trait colocalization; endothelial ATAC-seq (public datasets); RNA-seq; eQTL analysis; GWAS |
| Low Throughput Method: | Dual-luciferase reporter assay using 200-bp rs6853156 CRE1 C/T constructs; Sanger sequencing; CRISPRi; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | REST |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer