About Enhancer
| Enhancer ID: | E_02403 |
| Species: | Homo sapiens |
| Position : | chr2:226999986-227001986   |
| Year: | 2017 |
| Title: | Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | corneal astigmatism |
| PMID: | 28916725 |
| Tissue: | cornea |
| Tissue Ontology ID: | UBERON:0000964 |
| Cell Source: | primary human corneal epithelial cells |
| Cell Type: | corneal epithelial cell |
| Cell Ontology ID: | CL:0000575 |
| Experiment Type: | Disease-associated enhancer variant assay; TF binding assay |
| High Throughput Method: | H3K4me1/H3K27ac/H3K4me3 ChIP-seq; public ChIA-PET integration; expression profiling; ChIP-seq |
| Low Throughput Method: | Wild-type/variant luciferase reporter assay; EHF ChIP; EHF siRNA |
About Target Gene
| Target gene : | IRS1 |
About TF
| TF name : | EHF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EHF | PDGF signaling pathway | panther | 113 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer