About Enhancer
| Enhancer ID: | E_02408 |
| Species: | Homo sapiens |
| Position : | chr7:117228049-117229449   |
| Year: | 2012 |
| Title: | Transcriptional networks driving enhancer function in the CFTR gene. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 22671145 |
| Tissue: | intestine |
| Tissue Ontology ID: | UBERON:0000160 |
| Cell Source: | Caco-2 |
| CVCL ID: | CVCL_0025 |
| Cell Type: | intestinal epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | ChIP-chip/ChIP-seq support; DNase-seq locus context |
| Low Throughput Method: | DNase I footprinting; EMSA; ChIP-qPCR; site-directed motif mutagenesis; luciferase reporter assay; siRNA; RT-qPCR |
About Target Gene
| Target gene : | CFTR |
About TF
| TF name : | CDX2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CDX2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| CDX2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01471 | chr7:117227200-117229503 | intestinal epithelium | intestinal epithelial cell | NA |
| E_01472 | chr7:117227200-117229503 | intestinal epithelium | intestinal epithelial cell | NA |
| E_02405 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02406 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02407 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_01497 | chr7:117228051-117229440 | NA | NA | NA |
| E_01498 | chr7:117228051-117229440 | NA | NA | NA |
| E_01499 | chr7:117228051-117229440 | NA | NA | NA |
| E_01500 | chr7:117228051-117229440 | NA | NA | NA |
Expression of Target Genes for the Enhancer