About Enhancer
| Enhancer ID: | E_02412 |
| Species: | Mus musculus |
| Position : | chr7:35940000-35940455   |
| Year: | 2019 |
| Title: | HoxA9 binds and represses the Cebpa +8 kb enhancer |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 31120998 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary murine myeloid progenitor cells |
| CVCL ID: | |
| Cell Type: | myeloid progenitor cell |
| Cell Ontology ID: | CL:0000837 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Transgenic Reporter Assay, Flow Cytometry, RT-RT-qPCR |
About Target Gene
| Target gene : | Cebpa |
About TF
| TF name : | Hoxa9 |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Hoxa9 | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02413 | chr7:35940000-35940455 | Bone Marrow | common myeloid progenitor cell | acute myeloid leukemia |
| E_02414 | chr7:35940000-35940455 | Bone Marrow | granulocyte-monocyte progenitor cell | acute myeloid leukemia |
| E_02415 | chr7:35940000-35940455 | Bone Marrow | hematopoietic stem cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer