About Enhancer
| Enhancer ID: | E_02425 |
| Species: | Mus musculus |
| Position : | chr8:44910000-44930000   |
| Year: | 2018 |
| Title: | Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 29514092 |
| MONDO: | |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Ly6C+ classical monocytes |
| CVCL ID: | |
| Cell Type: | classical monocyte |
| Cell Ontology ID: | CL:0000576 |
| Experiment Type: | Immunological functional assay, Functional genomics assay, Epigenomic profiling assay, Transcriptional regulation assay, In vitro functional assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq [targets: H3K4me1, H3K27ac, Irf8], RNA-seq, Gene Expression Microarray |
| Low Throughput Method: | Flow Cytometry, FACS, qRT-PCR, ChIP-RT-qPCR, Western blot, Immunofluorescence Microscopy, In Vivo Hematopoietic Reconstitution Assay |
About Target Gene
| Target gene : | Bach2 |
About TF
| TF name : | Irf8; Spi1; Maf |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer