About Enhancer
| Enhancer ID: | E_02457 |
| Species: | Mus musculus |
| Position : | chr4:55630000-55650000   |
| Year: | 2018 |
| Title: | Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 29514092 |
| MONDO: | |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Monocyte-dendritic cell progenitor cells |
| CVCL ID: | |
| Cell Type: | monocyte-dendritic cell progenitor |
| Cell Ontology ID: | CL:0000837 |
| Experiment Type: | Immunological functional assay, Functional genomics assay, Epigenomic profiling assay, Transcriptional regulation assay, In vitro functional assay, In vivo functional assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Gene expression microarray |
| Low Throughput Method: | Flow cytometry, FACS, RT-RT-qPCR, ChIP-RT-qPCR, Western blot |
About Target Gene
| Target gene : | Klf4 |
About TF
| TF name : | Irf8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Irf8 | GMCSF-mediated signaling events | pid | 38 |
| Irf8 | Interferon alpha/beta signaling | reactome | 67 |
| Irf8 | Interferon gamma signaling | reactome | 88 |
| Irf8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Irf8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer