About Enhancer
| Enhancer ID: | E_02460 |
| Species: | Mus musculus |
| Position : | chr7:122684500-122685300   |
| Year: | 2016 |
| Title: | Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 26748758 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse embryonic stem cells (LF2 strain) |
| CVCL ID: | |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay, Germline specification assay |
| High Throughput Method: | ChIP-seq, Strand-specific RNA-seq |
| Low Throughput Method: | GFP reporter assay, ChIP-RT-qPCR, RT-RT-qPCR, Co-immunoprecipitation, Western blot, EpiLC differentiation assay, PGCLC induction assay, Flow cytometry |
About Target Gene
| Target gene : | Nanos3 |
About TF
| TF name : | Foxd3; Pou5F1; Sox2; Nanog |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer