About Enhancer
| Enhancer ID: | E_02464 |
| Species: | Homo sapiens |
| Position : | chr9:133252439-133252657   |
| Year: | 2016 |
| Title: | Epithelial Expression of Human ABO Blood Group Genes Is Dependent upon a Downstream Regulatory Element Functioning through an Epithelial Cell-specific Transcription Factor, Elf5. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27587399 |
| Tissue: | stomach |
| Tissue Ontology ID: | UBERON:0000945 |
| Cell Source: | KATO III |
| CVCL ID: | CVCL_0371 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Endogenous enhancer deletion; direct TF binding; enhancer activity and TF dependency; Enhancer activity assay; Endogenous enhancer perturbation; TF binding assay |
| High Throughput Method: | ENCODE DNase-seq/chromatin-state integration |
| Low Throughput Method: | CRISPR-Cas9 biallelic enhancer deletion; luciferase; EMSA; ChIP; motif mutation; ELF5 shRNA; flow cytometry; CRISPR-Cas9 endogenous deletion/editing; Luciferase reporter assay; shRNA knockdown; Allele-specific reporter assay |
About Target Gene
| Target gene : | ABO |
About TF
| TF name : | ELF5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ELF5 | PDGF signaling pathway | panther | 113 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer