About Enhancer
| Enhancer ID: | E_02465 |
| Species: | Mus musculus |
| Position : | chr15:52153900-52154520   |
| Year: | 2011 |
| Title: | The pancreatic islet ??-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 20942803 |
| MONDO: | |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | ??TC-3 |
| CVCL ID: | CVCL_B077 |
| Cell Type: | pancreatic beta cell |
| Cell Ontology ID: | CL:0000169 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, EMSA |
About Target Gene
| Target gene : | Slc30A8 |
About TF
| TF name : | Pdx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pdx1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Pdx1 | Regulation of gene expression in beta cells | reactome | 17 |
| Pdx1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| Pdx1 | Type II diabetes mellitus | kegg | 44 |
| Pdx1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer