About Enhancer
| Enhancer ID: | E_02481 |
| Species: | Homo sapiens |
| Position : | chr7:150700000-150705000   |
| Year: | 2018 |
| Title: | Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29348663 |
| Cell Source: | Endothelial Cells (ECs) |
| Cell Type: | endothelial cell |
| Cell Ontology ID: | CL:0000115 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | ChIP-seq; Hi-C; 4C-seq |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | NOS3 |
About TF
| TF name : | KLF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| KLF4 | Synthesis, secretion, and deacylation of Ghrelin | reactome | 17 |
| KLF4 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| KLF4 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF4 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| KLF4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| KLF4 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02480 | chr7:150700000-150705000 | NA | endothelial cell | NA |
Expression of Target Genes for the Enhancer