About Enhancer
| Enhancer ID: | E_02496 |
| Species: | Homo sapiens |
| Position : | chr8:128172101-128172473   |
| Year: | 2025 |
| Title: | Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 40067173 |
| MONDO: | MONDO:0018905 |
| Tissue: | lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | SU-DHL-5 |
| CVCL ID: | CVCL_1735 |
| Cell Type: | germinal center B cell |
| Cell Ontology ID: | CL:0000844 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| High Throughput Method: | NFR-focused CRISPRi screen; H3K27ac ChIP-seq; ATAC-seq |
| Low Throughput Method: | Individual CRISPRi; POU2F2 CRISPRi; qRT-PCR; Dual-Glo luciferase reporter assay; OCT2-motif deletion reporter assay; 195B tandem-duplication reporter assay; Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | POU2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F2 | BCR signaling pathway | pid | 70 |
| POU2F2 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03876 | chr8:126650000-129950000 | colon | malignant cell | NA |
| E_02497 | chr8:128172101-128172473 | lymph node | germinal center B cell | diffuse large B-cell lymphoma |
| E_02498 | chr8:128172101-128172473 | lymph node | germinal center B cell | diffuse large B-cell lymphoma |
| E_02499 | chr8:128172101-128172473 | ascitic fluid | germinal center B cell | diffuse large B-cell lymphoma |
| E_02500 | chr8:128172101-128172473 | ascitic fluid | germinal center B cell | diffuse large B-cell lymphoma |
| E_02501 | chr8:128172101-128172473 | ascitic fluid | germinal center B cell | diffuse large B-cell lymphoma |
| E_02572 | chr8:128172101-128172473 | inguinal part of abdomen | B cell | diffuse large B-cell lymphoma |
Expression of Target Genes for the Enhancer