About Enhancer
| Enhancer ID: | E_02500 |
| Species: | Homo sapiens |
| Position : | chr8:128172101-128172473   |
| Year: | 2025 |
| Title: | Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 40067173 |
| MONDO: | MONDO:0018905 |
| Tissue: | ascitic fluid |
| Tissue Ontology ID: | UBERON:0007795 |
| Cell Source: | HT |
| CVCL ID: | CVCL_1290 |
| Cell Type: | germinal center B cell |
| Cell Ontology ID: | CL:0000844 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| High Throughput Method: | H3K27ac ChIP-seq; ATAC-seq |
| Low Throughput Method: | Individual CRISPRi; POU2AF1 CRISPRi; qRT-PCR; Dual-Glo luciferase reporter assay; reporter assay with concurrent POU2AF1 CRISPRi; Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | POU2AF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03876 | chr8:126650000-129950000 | colon | malignant cell | NA |
| E_02496 | chr8:128172101-128172473 | lymph node | germinal center B cell | diffuse large B-cell lymphoma |
| E_02497 | chr8:128172101-128172473 | lymph node | germinal center B cell | diffuse large B-cell lymphoma |
| E_02498 | chr8:128172101-128172473 | lymph node | germinal center B cell | diffuse large B-cell lymphoma |
| E_02499 | chr8:128172101-128172473 | ascitic fluid | germinal center B cell | diffuse large B-cell lymphoma |
| E_02501 | chr8:128172101-128172473 | ascitic fluid | germinal center B cell | diffuse large B-cell lymphoma |
| E_02572 | chr8:128172101-128172473 | inguinal part of abdomen | B cell | diffuse large B-cell lymphoma |
Expression of Target Genes for the Enhancer