About Enhancer
| Enhancer ID: | E_02504 |
| Species: | Homo sapiens |
| Position : | chr8:129180000-129190000   |
| Year: | 2025 |
| Title: | Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 40067173 |
| MONDO: | MONDO:0018905 |
| Tissue: | lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | Karpas-422 |
| CVCL ID: | CVCL_1325 |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPRi, Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | POU2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F2 | BCR signaling pathway | pid | 70 |
| POU2F2 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00951 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_00974 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_00975 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_02502 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_02503 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_00949 | chr8:129188417-129189959 | lung | malignant cell | lung adenocarcinoma |
| E_00950 | chr8:129188417-129189959 | lung | malignant cell | lung adenocarcinoma |
| E_01020 | chr8:129188417-129189959 | lymph node | malignant cell | lung adenocarcinoma |
| E_01025 | chr8:129188417-129189959 | lung | club cell | lung adenocarcinoma |
Expression of Target Genes for the Enhancer